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Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion

  
@article{JTD21037,
	author = {Ji Young Hong and So Yeong Park and Youngmi Kim and Chang Youl Lee and Myung Goo Lee},
	title = {Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {5},
	year = {2018},
	keywords = {},
	abstract = {Background: Early diagnosis of tuberculous pleural effusion (TPE) remains difficult. Calpain is a family of calcium-dependent endopeptidase that plays an important role in extracellular matrix (ECM) remodeling and collagen synthesis. The aim of this study was to explore the diagnostic value of pleural fluid angiotensin-converting enzyme (ACE), calpain-1, spectrin breakdown products (SBDP), and matrix metalloproteinase-1 (MMP-1) in TPE and malignant pleural effusion (MPE).
Methods: The study included 47 patients with TPE, 28 patients with MPE, and 10 patients with transudate of non-tuberculous and non-malignant origin as controls. Calpain-1, ACE, SBDP, and MMP-1 levels in pleural fluid were measured by the ELISA method.
Results: ACE, calpain-1, SBDP, and MMP-1 levels were higher in TPE than MPE and transudate (all, P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/21037}
}