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Esophageal cancer in patients under 50: a SEER analysis

	author = {Yuan Zeng and Wenli Ruan and Jun Liu and Wenhua Liang and Jiaxi He and Fei Cui and Hui Pan and Jianxing He},
	title = {Esophageal cancer in patients under 50: a SEER analysis},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {5},
	year = {2018},
	keywords = {},
	abstract = {Background: Concomitant with rising rates of esophageal adenocarcinoma, there has been a significant increase of diagnoses among relatively younger individuals. However, most studies that focus on esophageal cancer (EC) in younger patients have had small sample sizes of patients treated at a single institute. The aim of this study was to analyze the clinical characteristics, outcomes and independent prognostic factors for EC in patients under 50-year-old using a large, multi-center dataset.
Methods: The national Surveillance, Epidemiology, and End Results (SEER) database was analyzed for EC reported from 2004 to 2013. Patients were divided into two groups, those under 50-year-old and those  50 years or older, and comparisons were made regarding demographics, histology, stage distribution, treatment, overall survival (OS), and esophageal cancer-specific survival (ECSS). Multivariate Cox proportional hazard regression analyses were also used to identify independent prognostic factors. 
Results: Among the 16,544 eligible patients, 1,385 (8.37%) were under 50 and 15,159 (91.63%) were over 50. Compared with the older group, patients under 50 were characterized by a higher frequency of males, lower esophagus involvement, adenocarcinoma histology, stage III/IV disease, and receiving esophagectomy or radiation therapy. The stage-wise OS and ECSS were significantly better in the younger group (P},
	issn = {2077-6624},	url = {}