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Extended resections of large thymomas: importance of en bloc thymectomy

	author = {José Francisco Corona-Cruz and Raúl Alejandro López-Saucedo and Laura Alejandra Ramírez-Tirado and Delia Pérez-Montiel and Josué Andrés González-Luna and Edgardo Jiménez-Fuentes and Oscar Arrieta},
	title = {Extended resections of large thymomas: importance of  en bloc  thymectomy},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {6},
	year = {2018},
	keywords = {},
	abstract = {Background: Primary tumors of the thymus are rare; the most common histologic type is thymoma. Most important prognostic factors are anatomical extent of tumor and completeness of surgical resection. Large size has not been directly associated with survival, but is strongly associated with advanced disease and high rates of incomplete resections. 
Methods: A retrospective cohort of patients who underwent thymectomy for thymomas of 5 cm or larger at the National Cancer Institute (INCan) of México from January 2005 to December 2016 was analyzed. Primary end-points were rate of complete resection, morbidity and mortality of thymectomy. Secondary end-points were overall survival (OS) and disease-free survival (DFS). 
Results: A total of 25 patients were identified and included in the final analysis. Mean age was 56.6 years (27–82 years). Median size of thymoma was 8.3 cm (5–14 cm). Transesternal approach was used in 72% of cases, most of cases (68%) required an extended resection to achieve negative margins. Complete resection was achieved on 23 cases (92%). A 90-day morbidity of 24% and mortality of 8% was found, with a median follow-up of 34.5 months (1–113 months). The only factor associated with OS was completeness of surgical resection (P},
	issn = {2077-6624},	url = {}