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Impact of major bleeding on the risk of acute kidney injury in patients undergoing off-pump coronary artery bypass grafting

  
@article{JTD21664,
	author = {Wei Liu and Ziwei Xi and Chengxiong Gu and Ran Dong and Jumana AlHelal and Zhenxian Yan},
	title = {Impact of major bleeding on the risk of acute kidney injury in patients undergoing off-pump coronary artery bypass grafting},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {6},
	year = {2018},
	keywords = {},
	abstract = {Background: Patients with perioperative bleeding during cardiac surgery are susceptible to acute kidney injury (AKI) which is proposed to be associated with short-term and long-term risk of adverse events. The relationship between perioperative bleeding in off-pump coronary artery bypass grafting (OPCAB) and AKI remains unknown. The purpose of this study is to evaluate the impact of perioperative bleeding on the risk of postoperative AKI in patient undergoing OPCAB.
Methods: Perioperative major bleeding was defined by the universal definition of perioperative bleeding (UDPB) class 3 to 4. The primary endpoint was postoperative AKI which was diagnosed using criteria of stage 1 of AKI proposed by Acute Kidney Injury Network (AKIN). The secondary endpoints included in-hospital mortality and the incidence of postoperative myocardial infarction (MI). Baseline characteristics were compared between patients with and without major bleeding. Multivariable logistic regression analysis was performed to identify potential predictive factors for AKI after OPCAB.
Results: A total of 4,030 ACS (acute coronary syndrome) patients who underwent OPCAB were included in this study. Major bleeding rate was 9.8% (n =394). AKI was found in 995 (24.7%) patients. Multivariable regression analysis showed that perioperative major bleeding conferred a significantly higher risk of AKI after OPCAB with an odds ratio of 1.67 (95% confidence interval 1.32–2.10, P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/21664}
}