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Neuregulin1 acts as a suppressor in human lung adenocarcinoma via AKT and ERK1/2 pathway

	author = {Youya Wang and Zhifeng Ning and Xuefeng Zhou and Zetian Yang and Hexiao Tang and Ming Xu and Xianguo Wang and Jinping Zhao and Yuting Bai},
	title = {Neuregulin1 acts as a suppressor in human lung adenocarcinoma via AKT and ERK1/2 pathway},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {6},
	year = {2018},
	keywords = {},
	abstract = {Background: Neuregulin1 (NRG1) is critical signaling protein that mediates the activation of downstream signaling pathways associated with malignancies. Multiple gene fusions related to NRG1 have been found in lung cancer. However, the underlying role NRG1 in lung cancer is yet unclear. Therefore, the present study investigated the biological functions on human lung adenocarcinoma (LUAD).
Methods: The expression of NRG1 was detected in LUAD tissues by Western blot (WB), quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). The expression of NRG1 was upregulated by the addition of exogenous NRG1 and downregulated by small interfering RNA (siRNA), and the biological behaviors of LUAD cells were assessed: cell proliferation by MTT assay, cell cycle and apoptosis by flow cytometry analysis, and migration and invasion using Transwell system. Finally, the pathway underlying the cellular function was analyzed by WB.
Results: A lower expression of NRG1 was observed in LUAD cancer tissues (P},
	issn = {2077-6624},	url = {}