@article{JTD22241,
author = {Jiacheng Yin and Yong Yang and Ke Ma and Xiaodong Yang and Tao Lu and Shuai Wang and Yu Shi and Cheng Zhan and Yimeng Zhu and Qun Wang},
title = {Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {7},
year = {2018},
keywords = {},
abstract = {Background: Pulmonary pleomorphic carcinoma (PPC) is a rare malignancy; unique clinicopathological characteristics and prognosis have not been described.
Methods: PPC patient information collected in the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2014 were extracted, evaluated, and compared with NSCLC patient data. Overall survival (OS) was evaluated by the Kaplan-Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS and the results were used to construct a nomogram to predict 1-, 3-, and 5-year OS in PPC patients.
Results: A total of 309 patients diagnosed with PPC were identified among the records of 320,510 NSCLC patients. The median age was 66 (IQR, 57–75) years, 59.2% were men, 79.3% were white, 63.9% had upper lobe tumors, 77.0% were poorly differentiated, and 38.0% were AJCC stage IV. Median OS was 9 (95% CI: 6.69–11.31) months and 5-year OS was 25.1% (95% CI: 23.6–26.6%). PPC patients had significantly larger and less differentiated tumors, a higher rate of radical surgical resection, less N+ disease, and fewer distant metastases (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/22241}
}