%0 Journal Article %T The role of plasma miRNAs in the diagnosis of pulmonary nodules %A Xi, Ke-Xing %A Zhang, Xue-Wen %A Yu, Xiang-Yang %A Wang, Wei-Dong %A Xi, Ke-Xiang %A Chen, Yong-Qiang %A Wen, Ying-Sheng %A Zhang, Lan-Jun %J Journal of Thoracic Disease %D 2018 %B 2018 %9 %! The role of plasma miRNAs in the diagnosis of pulmonary nodules %K %X Background: In this study, we aimed to assess the clinical utility of detection of plasma microRNAs (miRNAs) in the diagnosis of pulmonary nodules. Methods: Fifty-seven patients with pulmonary nodules who had undergone surgery were enrolled in our study from July 2016 to July 2017 at Sun Yat-sen University Cancer Center. We measured the expression levels of 12 miRNAs (miRNA-17, -146a, -200b, -182, -155, -221, -205, -126, -7, -21, -145, and miRNA-210) in plasma samples of 57 patients, including 15 benign pulmonary nodules patients and 42 malignant pulmonary nodules patients. The levels of these miRNAs were detected by Real-time quantitative polymerase chain reaction (RT-PCR). The receiver operating characteristic (ROC) curve was used to assess the diagnostic performance of plasma miRNAs for non-small cell lung cancer (NSCLC). Results: The expression levels of plasma miRNA-17, -146a, -200b, -182, -155, -221, -205, -126, -7, -21, -145, and miRNA-210 are not associated with gender, age, pTNM stage, differentiation grade. The levels of miRNA-17, -146a, -200b, -182, -221, -205, -7, -21, -145, and miRNA-210 in NSCLC patients are significantly higher than those in benign pulmonary nodules patients (P Conclusions: Plasma miRNAs (miRNA-17, -146a, -200b, -182, -221, -205, -7, -21, -145, and miRNA-210) have relatively high sensitivity and specificity for the diagnosis of NSCLC. These plasma miRNAs may be the potential biomarkers for early diagnosis of lung cancer. %U https://jtd.amegroups.org/article/view/22438 %V 10 %N 7 %P 4032-4041 %@ 2077-6624