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Tumor mutational burden (TMB) as a biomarker of response to immunotherapy in small cell lung cancer

  
@article{JTD23082,
	author = {Yanis Boumber},
	title = {Tumor mutational burden (TMB) as a biomarker of response to immunotherapy in small cell lung cancer},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {8},
	year = {2018},
	keywords = {},
	abstract = {Tumors avoid immune surveillance by inactivating various T-cell cytotoxic pathways that can promote cell death (1-3). Cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1) are expressed primarily on cytotoxic T lymphocytes. In contrast, programmed death ligand 1 (PD-L1) is expressed on antigen-presenting lymphoid and non-lymphoid tissues, on tumor cells, and on virus-infected cells.},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/23082}
}