TY - JOUR AU - Nikaido, Takefumi AU - Tanino, Yoshinori AU - Wang, Xintao AU - Sato, Yuki AU - Togawa, Ryuichi AU - Kikuchi, Masami AU - Misa, Kenichi AU - Saito, Kazue AU - Fukuhara, Naoko AU - Kawamata, Takaya AU - Rikimaru, Mami AU - Umeda, Takashi AU - Morimoto, Julia AU - Koizumi, Tatsuhiko AU - Suzuki, Yasuhito AU - Hirai, Kenichiro AU - Uematsu, Manabu AU - Minemura, Hiroyuki AU - Fukuhara, Atsuro AU - Sato, Suguru AU - Saito, Junpei AU - Yokouchi, Hiroshi AU - Kanazawa, Kenya AU - Shibata, Yoko PY - 2018 TI - Serum decorin is a potential prognostic biomarker in patients with acute exacerbation of idiopathic pulmonary fibrosis JF - Journal of Thoracic Disease; Vol 10, No 9 (September 28, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Background: Decorin is a small leucine-rich repeat proteoglycan that plays a critical role in collagen fibrillogenesis, and regulates inflammation, wound healing and angiogenesis. In idiopathic pulmonary fibrosis (IPF), decorin is expressed in fibrotic lesions; furthermore, intratracheal gene transfer of decorin has been demonstrated to inhibit bleomycin-induced pulmonary fibrosis. Although these results suggest the critical role of decorin in pulmonary fibrosis, the role of decorin in the acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) has not been clarified in detail. Thus, the goal of this study was to determine the role of decorin in AE-IIP. Methods: We retrospectively analyzed AE-IIP patients who had been admitted to our hospital. First, serum decorin levels were compared among patients with AE-IIP, patients with stable idiopathic interstitial pneumonia (SD-IIP), and healthy subjects. Next, the relationship between serum decorin levels and clinical parameters was analyzed in AE-IIP patients. Finally, the association between serum decorin levels and prognosis was evaluated in AE-IIP patients. IIP was divided into IPF and non-IPF, according to the published guidelines. Results: The serum decorin levels of AE-IIP patients were significantly lower than those of both healthy subjects and SD-IIP patients. Serum decorin levels were not related with the clinical parameters and prognosis, when all IIP patients were analyzed. In IPF patients, serum decorin levels had a significant correlation with oxygenation, and IPF patients with low serum decorin levels had a significantly higher survival rate than those with high serum decorin levels. Conclusions: Serum decorin levels are a potential prognostic biomarker in AE-IPF. UR - https://jtd.amegroups.org/article/view/23805