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Micropapillary or solid pattern predicts recurrence free survival benefit from adjuvant chemotherapy in patients with stage IB lung adenocarcinoma

  
@article{JTD23869,
	author = {Minjie Ma and Yunlang She and Yijiu Ren and Chenyang Dai and Lei Zhang and Huikang Xie and Chunyan Wu and Minglei Yang and Dong Xie and Chang Chen},
	title = {Micropapillary or solid pattern predicts recurrence free survival benefit from adjuvant chemotherapy in patients with stage IB lung adenocarcinoma},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {9},
	year = {2018},
	keywords = {},
	abstract = {Background: Our study aimed to evaluate the prognostic significance and adjuvant chemotherapy (ACT) benefits of a micropapillary/solid (MS) pattern in patients with stage IB lung adenocarcinoma.
Methods: Patients with pathologically-confirmed stage IB adenocarcinoma who underwent surgical resection between January 2009 and December 2011 were included. The tumors were reclassified into three categories: MS patterns absent (MS−); non-predominant MS patterns (MS+); predominant MS (MS++). The correlations of prognosis and ACT with recurrence-free survival (RFS) were evaluated.
Results: Overall, 497 (MS−, n=269; MS+, n=177; MS++, n=51) patients were enrolled in the study. In univariate analysis, the MS+ [hazard ratio (HR), 1.437; 95% confidence interval (CI), 1.030–2.006; P=0.033] and MS++ (HR, 2.818; 95% CI, 1.792–4.432; P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/23869}
}