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Obstructive sleep apnea in patients with chronic thromboembolic pulmonary hypertension

	author = {Xue Yu and Zhiwei Huang and Yi Zhang and Zhihong Liu and Qin Luo and Zhihui Zhao and Qing Zhao and Liu Gao and Qi Jin and Lu Yan},
	title = {Obstructive sleep apnea in patients with chronic thromboembolic pulmonary hypertension},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {10},
	year = {2018},
	keywords = {},
	abstract = {Background: Due to its effects, like an exaggerated negative intrathoracic pressure, sympathetic activation, systemic inflammation, oxidative stress, and endothelial dysfunction, obstructive sleep apnea (OSA) has been involved as a cause in multiple cardiovascular diseases. These diseases include coronary artery disease, hypertension, heart failure, and pulmonary hypertension (PH). Furthermore, OSA often coexists with chronic thromboembolic pulmonary hypertension (CTEPH) in clinical practice. However, few studies focus on OSA and its relationship with CTEPH. This study aims to determine whether OSA has an influence on the clinic status of patients with CTEPH, and to identify what possible factors are associated with OSA in CTEPH.
Methods: Patients who were newly diagnosed with CTEPH and received overnight polysomnography (PSG) monitoring from September 2015 to December 2017 were enrolled. OSA was defined as apnea-hypopnea index (AHI) of ≥5/h and the obstructive events at ≥50%. Baseline clinical characteristics and parameters were collected and compared between CTEPH patients with and without OSA. In addition, logistic regression analysis was performed to identify possible factors associated with OSA in CTEPH. 
Results: Fifty-seven patients with CTEPH were eventually enrolled. Among them, 32 patients were diagnosed with OSA by PSG. CTEPH patients with OSA showed an older age, a higher body mass index (BMI), a higher hemoglobin level, a lower oxygen saturation and a worse World Health Organization functional class (WHO FC) (all P},
	issn = {2077-6624},	url = {}