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A combined subtype of small cell lung cancer and adenocarcinoma with epidermal growth factor receptor (EGFR) mutation responds to EGFR tyrosine kinase inhibitors

  
@article{JTD24487,
	author = {Yong Zhang and Ling Ye and Huijun Zhang and Xuehua Chen and Haiying Ji and Gang Chen and Lu Zhang and Tengfei Zhang and Meiling Jin},
	title = {A combined subtype of small cell lung cancer and adenocarcinoma with epidermal growth factor receptor (EGFR) mutation responds to EGFR tyrosine kinase inhibitors},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {10},
	year = {2018},
	keywords = {},
	abstract = {Lung cancer is the leading cause of cancer death worldwide (1). Non-small cell lung cancer (NSCLC) causes 85% of the cases, and small cell lung cancer (SCLC) accounts for the other 15% (2). Activating alterations of epidermal growth factor receptor (EGFR) lead to 10–15% and 30–40% of NSCLC, especially adenocarcinoma, in Caucasus and Asian patients (3). In contrast, EGFR mutations are extremely rare in SCLC (4). However, some patients exhibit a combination subtype of SCLC and adenocarcinoma with EGFR mutation, which have been poorly investigated in terms of effective targeted therapeutic strategy.},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/24487}
}