TY - JOUR AU - Colli, Andrea AU - Bizzotto, Eleonora AU - Besola, Laura AU - Gregori, Dario AU - Toto, Francesca AU - Manzan, Erica AU - Gerosa, Gino PY - 2018 TI - Risk stratification of severe aortic stenosis according to new guidelines: long term outcomes JF - Journal of Thoracic Disease; Vol 10, No 10 (October 26, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Background: Current ESC and ACC/AHA guidelines for the management of valvular heart disease assign a class Ia indication for aortic valve replacement (AVR) only to patients with symptomatic severe aortic valve stenosis and asymptomatic patients with depressed left ventricular ejection fraction (LVEF Methods: Patients who had undergone isolated AVR for severe aortic valve stenosis between January 2001 and December 2012 were selected. The population was divided into subgroups based on preoperative LVEF ( Results: We identified 607 patients with a median follow-up (FU) time of 5.75 years (IQR 3.24–8.00 years). The presence of symptoms did not have a significant impact on cardiovascular mortality (P=0.201). Patients with LVEF Conclusions: According to our data, current international class I indications for symptomatic patients ensure good long-term survival, while class I indications for asymptomatic patients with reduced LVEF are associated with poor long-term survival. Our results suggest that early surgery should also be considered also for asymptomatic patients with preserved LVEF, particularly in cases of very low operative risk. UR - https://jtd.amegroups.org/article/view/24692