TY - JOUR AU - Pezzuto, Federica AU - Fortarezza, Francesco AU - Lunardi, Francesca AU - Calabrese, Fiorella PY - 2018 TI - Are there any theranostic biomarkers in small cell lung carcinoma? JF - Journal of Thoracic Disease; Vol 11, Supplement 1 (January 25, 2019): Journal of Thoracic Disease (Advances in Theranostic Biomarkers for Lung Cancer: from Clinical to Molecular Pathology) Y2 - 2018 KW - N2 - Small cell lung cancer (SCLC), an aggressive lung tumour with a poor prognosis, has a high load of somatic mutations, mainly induced by tobacco carcinogens given the strong association with smoking. Advances in genomic, epigenetic and proteomic profiling have significantly improved our understanding of the molecular and cellular biology of SCLC. Given the high mutational burden of SCLC the immune microenvironment is another exciting area under investigation even if it seems to be quite distinct from that of other solid tumours. In this review we will outline the current progress in molecular etiology of SCLC mentioning some key markers considered promising theranostic biomarkers. UR - https://jtd.amegroups.org/article/view/25923