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Galactomannan detection in bronchoalveolar lavage fluid corrected by urea dilution for the diagnosis of invasive pulmonary aspergillosis among nonneutropenic patients

  
@article{JTD26474,
	author = {Yuetian Yu and Cheng Zhu and Hui Shen and Chunyan Liu and Ruru Guo and Yuan Gao and Wenjuan Wu and Liangjing Lu},
	title = {Galactomannan detection in bronchoalveolar lavage fluid corrected by urea dilution for the diagnosis of invasive pulmonary aspergillosis among nonneutropenic patients},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: To investigate the diagnostic performance of galactomannan (GM) detection in bronchoalveolar lavage fluid (BALF) corrected by urea dilution and modification of the AspICU clinical algorithm. 
Methods: GM detection in serum and BALF samples was performed in nonneutropenic patients on the day of clinically suspected invasive pulmonary aspergillosis (IPA) between January 2016 and June 2018, and urea was measured in the plasma and BALF. The BALF GM concentration was corrected by urea dilution, and receiver operating characteristic (ROC) curves were generated to determine the optimal cut-off value. 
Results: A total of 184 patients who were suspected of IPA, were enrolled in this prospective study together with 30 patients with lung cancer as a control group. Seventy-eight patients were diagnosed with IPA, including 37 who were verified by pathology. The urea plasma-to-urea BALF ratio in the IPA group [4.18 (IQR, 3.52–4.91)] was greater than that in the non-IPA group [3.42 (IQR, 3.12–3.76), P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/26474}
}