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Long-term impact of complications after lung resections in non-small cell lung cancer

  
@article{JTD28676,
	author = {Shuichi Shinohara and Kenichi Kobayashi and Chinatsu Kasahara and Takamitsu Onitsuka and Masaki Matsuo and Makoto Nakagawa and Masakazu Sugaya},
	title = {Long-term impact of complications after lung resections in non-small cell lung cancer},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {5},
	year = {2019},
	keywords = {},
	abstract = {Background: Postoperative complications after lung resection are common and fatal. The immediate effects of postoperative complications are related to poor prognosis; however, the long-term effects have not been assessed. Thus, this investigation aimed to clarify the long-term effects of postoperative complications among patients with resected non-small cell lung cancer (NSCLC).
Methods: This retrospective cohort study included 345 patients with resected NSCLC from a single institution. We used the Clavien-Dindo classification to classify postoperative complications. Postoperative complications were defined as complications with a Clavien-Dindo grade of ≥2. The Kaplan-Meier method was used to evaluate survival. Prognostic factors were analyzed using a Cox proportional hazard model. 
Results: There were 110 patients with postoperative complications (31.9%). The 5-year overall survival (OS), recurrence-free survival (RFS), and cause-specific survival (CSS) rates were significantly lower in patients with complications than in those without complications [OS: 66.1%, 95% confidence interval (CI): 55.4–74.8% vs. 78.0%, 95% CI: 71.8–83.1%, P=0.001; RFS: 48.8%, 95% CI: 38.1–58.7% vs. 70.8%, 95% CI: 64.2–76.4%, P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/28676}
}