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A prospective randomized comparative study of high-flow nasal cannula oxygen and non-invasive ventilation in hypoxemic patients undergoing diagnostic flexible bronchoscopy

  
@article{JTD28823,
	author = {Bancha Saksitthichok and Tananchai Petnak and Apichart So-ngern and Viboon Boonsarngsuk},
	title = {A prospective randomized comparative study of high-flow nasal cannula oxygen and non-invasive ventilation in hypoxemic patients undergoing diagnostic flexible bronchoscopy},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {5},
	year = {2019},
	keywords = {},
	abstract = {Background: Although oxygen supplementation during bronchoscopy in patients with pre-existing hypoxemia is provided, adequacy of oxygenation may not be achieved, resulting in the occurrence of respiratory failure that requires endotracheal tube intubation. The purpose of this study was to compare high-flow nasal cannula (HFNC) with non-invasive ventilation (NIV) in patients with pre-existing hypoxemia undergoing flexible bronchoscopy (FB) on the ability to maintain oxygen saturation during bronchoscopy. 
Methods: A prospective randomized study was conducted in patients who had hypoxemia [defined as partial pressure of arterial oxygen (PaO2) less than 70 mmHg at room air] and required FB for the diagnosis of abnormal pulmonary lesions. Patients were randomized to receive either HFNC or NIV during FB. The primary outcome was the lowest oxygen saturation level during FB.
Results: Fifty-one patients underwent randomization to HFNC (n=26) or NIV (n=25). Baseline characteristics in terms of age, Simplified Acute Physiologic Score II values, and cardiorespiratory parameters were similar in both groups. After receiving HFNC or NIV, oxygen saturation as measured by pulse oximeter (SpO2) increased to greater than 90% in all cases. During FB, although the lowest SpO2 was similar in both groups, the lowest SpO2 },
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/28823}
}