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Management of non-small cell lung cancer harboring epidermal growth factor receptor mutations in the era of first-line osimertinib

   
@article{JTD29309,
	author = {Taiki Hakozaki and Yusuke Okuma},
	title = {Management of non-small cell lung cancer harboring epidermal growth factor receptor mutations in the era of first-line osimertinib},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {7},
	year = {2019},
	keywords = {},
	abstract = {Osimertinib (AZD9291, Tagrisso™), a third-generation irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has brought about rapid transformative changes to the treatment of EGFR-mutation-positive advanced non-small cell lung cancer (NSCLC). After acquiring resistance to first- or second-generation EGFR-TKIs, osimertinib showed greater efficacy than the combination of pemetrexed and platinum-based chemotherapy in patients with the exon 20 T790M resistance mutation in the AURA3 trial (1).},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/29309}
}