TY - JOUR AU - Yuan, Yafei AU - Li, Bohou AU - Huang, Minyu AU - Peng, Xianru AU - Zhao, Wenqu AU - Ye, Yanmei AU - Zhang, Peifang AU - Yu, Changhui AU - Dong, Hangming AU - Cai, Shaoxi AU - Zhao, Haijin PY - 2019 TI - Fractional exhaled nitric oxide was not associated with the future risk of exacerbations in Chinese asthmatics: a non-interventional 1-year real-world study JF - Journal of Thoracic Disease; Vol 11, No 6 (June 29, 2019): Journal of Thoracic Disease Y2 - 2019 KW - N2 - Background: Exacerbations are recognized as the most relevant predictor of future risk in asthmatics. We aimed to evaluate the association between asthma exacerbations, fractional exhaled nitric oxide (FENO), spirometry indices, and other potential risk factors in a non-interventional, real-world study performed in Guangzhou, China. Methods: We performed a prospective 12 months follow-up of Chinese asthmatics. Spirometry and FENO measurements were performed at baseline. Adherence to inhaled corticosteroids (ICS) use was divided into two categories (>80% and Results: A total of 222 patients with asthma (49.1% males) completed the study, of which 51 (23.0%) experienced exacerbations during the study period. Of the patients, 117 (52.7%) had good compliance. We compared lung function indices between the patients with and without exacerbations. There was no difference of forced expiratory volume in 1 s (FEV1) predicted, forced vital capacity (FVC) predicted, and FEVI/FVC (all, P>0.05) between the groups. There was also no significant difference in FENO level between the two groups. Compared to those that had exacerbations, patients without exacerbations had better treatment compliance (P Conclusions: Poor adherence rather than baseline FENO and FEV1% predicted was associated with the future risk of exacerbations in Chinese asthmatics in real world. UR - https://jtd.amegroups.org/article/view/29498