%0 Journal Article %T Age at diagnosis is a heterogeneous factor for non-small cell lung cancer patients %A Chen, Tao %A Zhou, Fangyu %A Jiang, Weili %A Mao, Rui %A Zheng, Hui %A Qin, Linlin %A Chen, Chang %J Journal of Thoracic Disease %D 2019 %B 2019 %9 %! Age at diagnosis is a heterogeneous factor for non-small cell lung cancer patients %K %X Background: The incidence of lung cancer is reported as age dependent. However, the link between survival and age at diagnosis remains controversial. To date, few studies have examined the relationship between age and the clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC). Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we included in our analysis 151,919 patients diagnosed with NSCLC between 2004 and 2013. Logistic regression was used to evaluate the associations between age and clinicopathological characteristics. N and M stages were separately assessed in each T stage. Results: Of the patients enrolled, 60,271 patients were diagnosed at the M1 stage, 147,263 patients had lymph node metastasis, and 49,862 patients underwent surgery. Younger age was inversely associated with high N stage and M stage (P Conclusions: Age at diagnosis is a heterogeneous factor for NSCLC patients: younger patients have an increased risk of lymph node and distant metastases, yet have a better prognosis. %U https://jtd.amegroups.org/article/view/29501 %V 11 %N 6 %P 2251-2266 %@ 2077-6624