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Favorable clinical application for segmental bronchial closure based on experiment results

	author = {Hiroaki Kuroda and Yusuke Sugita and Keita Nakanishi and Yuko Oya and Noriaki Sakakura and Yukinori Sakao},
	title = {Favorable clinical application for segmental bronchial closure based on experiment results},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {6},
	year = {2019},
	keywords = {},
	abstract = {Background: We previously reported the clinical application of powered vascular staple (PVS) for closure of subsegmental or segmental bronchus (SSB). This study aimed to measure breakdown pressure in experiment and to investigate bronchopleural fistula (BPF) after thoracoscopic segmentectomy (TS). 
Methods: Part 1: a total of 30 cadaveric pigs were used, and bronchi were categorized into the following four groups: small [S, bronchial outer diameter (BOD) of 4ā€“8 mm, n=8], medium (M, 9ā€“10 mm, n=9), and large (L, >10 mm, n=13). We additionally added a single additional suture to compensate for weak sites with large BOD (group R, n=6). The pressure was slowly increased, and stump breakdown was observed. Part 2: we investigated the morbidity of BPF formation at follow-up of at least 6 months in a total of 217 patients. 
Results: Part 1: the mean leak pressure was the highest in M, followed by groups S, R and Lā€™. However, the significant difference was not found between S and R. Part 2: no BPF was observed, clinically. 
Conclusions: Based on experimental results and clinical experience, the proper selection of PVS should contribute to the safety, feasibility, and success as SSB closure.},
	issn = {2077-6624},	url = {}