@article{JTD30809,
author = {Baofu Chen and Junhong Lin and Yuhang Ruan and Zixuan Chen and Kaya Petersen and Min Kong and Jianfei Shen and Gongchao Wang},
title = {The influence of adjuvant radiation therapy after endoscopic resection on survival for early stage EC: an analysis of the surveillance epidemiology and end results (SEER) database},
journal = {Journal of Thoracic Disease},
volume = {11},
number = {8},
year = {2019},
keywords = {},
abstract = {Background: Endoscopic resection (ER) followed by radiation therapy (RT) is a treatment option for early stage esophageal cancer (EC). We used the surveillance epidemiology and end results (SEER) database to investigate the influence of adjuvant RT after ER on survival for early stage EC.
Methods: The SEER database [1998–2013] was queried for locoregional cases of EC. Tumor staging was redefined with the 8th Edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control tumor-node-metastasis (TNM) staging system. The T1-2 stage EC cases in which ER were followed by radiation or observation were included. Kaplan-Meier methods were performed to compare overall survival (OS) and cancer-specific survival (CSS) between the patients who received radiation and those who did not. Subgroup analysis was made according to AJCC stage. A multivariate Cox proportional-hazards regression model was used to identify independent covariates which may influence survival.
Results: The median survival of the no-radiation group was significantly longer than that of the radiation group [74 vs. 31 months; hazard risk (HR), 2.39; 95% confidence interval (CI), 1.782–3.197; P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/30809}
}