%0 Journal Article %T Renal hemodynamics by return cannular position of extracorporeal membrane oxygenation in swine %A Kim, Hee Jung %A Jeong, Seong Cheol %A Jung, Jae Seung %A Kim, In Seup %A Lim, Choon-Hak %A Son, Ho Sung %J Journal of Thoracic Disease %D 2019 %B 2019 %9 %! Renal hemodynamics by return cannular position of extracorporeal membrane oxygenation in swine %K %X Background: Whether arterial return cannula position affects the kidney during Veno-Arterial extracorporeal membrane oxygenation (ECMO) is unclear. Therefore, we compared hemodynamic parameters and acute kidney injury (AKI) biomarkers between ascending aorta return (aECMO) and femoral artery return ECMO (fECMO) in swine to evaluate the effect of cannula position on the kidney. Methods: A total of twelve swines were allocated randomly into two groups. ECMO was maintained for 6h. Hemodynamic parameters including mean arterial pressure (MAP), renal arterial flow rate (AF), energy equivalent pressure (EEP), and surplus hemodynamic energy (SHE) were measured at the left renal artery. For evaluation of kidney injury, samples were obtained for blood urea nitrogen, creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin (before ECMO, and 1, 3, and 6 h after initiating ECMO). Results: Before the start of ECMO, hemodynamic parameters were not different between the two groups. With regard to the rate of change before and after ECMO, the fECMO group showed a significantly higher increase in MAP, AF, and EEP and a greater decrease in SHE than the aECMO group (P<0.001). In inter-group analysis, no significant difference in time-dependent trends were observed for biochemical laboratory levels. Conclusions: fECMO support was associated with a higher energy profile at the renal artery than that with aECMO, whereas pulsatility was decreased. %U https://jtd.amegroups.org/article/view/32523 %V 11 %N 10 %P 4211-4217 %@ 2077-6624