TY - JOUR AU - Yang, Xiaobo AU - Shang, You AU - Yuan, Shiying PY - 2019 TI - Low versus high pulse oxygen saturation directed oxygen therapy in critically ill patients: a randomized controlled pilot study JF - Journal of Thoracic Disease; Vol 11, No 10 (October 30, 2019): Journal of Thoracic Disease Y2 - 2019 KW - N2 - Background: Data on the safety and feasibility of pulse oxygen saturation (SpO 2 ) directed oxygen therapy in mainland China are scarce. The aim of this pilot study was to test the feasibility of SpO 2 directed oxygen therapy and to calculate sample size base on differences in 28-day mortality rates for a large sample-sized randomized trial. Methods: This prospective pilot study enrolled 214 adult patients with an expected intensive care unit (ICU) stay of more than 72 hours. Patients were randomized into a low SpO 2 group (SpO 2 90–95%) or high SpO 2 group (SpO 2 96–100%). The primary outcome was 28-day mortality. Results: One hundred patients were included in the low SpO 2 group, and 114 patients were included in the high SpO 2 group. The demographic and baseline characteristics were not different. The time-weighted SpO 2 average was significantly lower in the low SpO 2 group than in the high SpO 2 group [mean ± standard deviation (SD), 95.7%±2.3% vs. 98.2%±1.8%, P<0.001]. Twenty-six patients (26%) in the low SpO 2 group died within 28 days after inclusion, while 37 patients (32.5%) in the high SpO 2 group died (P=0.301). The time to death within 28 days between the two groups was not different (P=0.284). Conclusions: SpO 2 directed oxygen therapy in critically ill patients was feasible. Our pilot trial necessitates and rationalizes our large-sample multicenter trial. UR - https://jtd.amegroups.org/article/view/32731