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Early norepinephrine use in septic shock

	author = {Olfa Hamzaoui and Rui Shi},
	title = {Early norepinephrine use in septic shock},
	journal = {Journal of Thoracic Disease},
	volume = {12},
	number = {S1},
	year = {2020},
	keywords = {},
	abstract = {As vascular tone depression is a hallmark of septic shock, administration of norepinephrine is logical in this setting. In this article, we provide and develop the following arguments for an early use of norepinephrine—the recommended first-line vasopressor—in septic shock: (I) prevention of prolonged severe hypotension, (II) increase in cardiac output through an increase in cardiac preload and/or contractility, (III) improvement of microcirculation and tissue oxygenation, (IV) prevention of fluid overload, and (V) improvement of outcome. Presence of a low diastolic arterial pressure as a marker of depressed vascular tone can be used as a trigger to initiate norepinephrine urgently.},
	issn = {2077-6624},	url = {}