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Capillary refill time: the missing link between macrocirculation and microcirculation in septic shock?

   
@article{JTD34872,
	author = {Glenn Hernández and Ricardo Castro and Jan Bakker},
	title = {Capillary refill time: the missing link between macrocirculation and microcirculation in septic shock?},
	journal = {Journal of Thoracic Disease},
	volume = {12},
	number = {3},
	year = {2020},
	keywords = {},
	abstract = {ANDROMEDA-SHOCK was a multicenter, randomized controlled trial comparing capillary refill time (CRT)- versus lactate-targeted resuscitation in patients with early septic shock (1). The protocol mandated sequential steps starting with fluid challenges, followed by vasoactive-related interventions if necessary, until the target was reached. CRT-targeted resuscitation was associated with lower mortality (34.9% vs. 43.4%; P=0.06), beneficial effects on organ dysfunction, and less treatment intensity. A strong survival benefit was also supported by a recently published post-hoc Bayesian analysis (2).},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/34872}
}