TY - JOUR AU - Chen, Allan Y. AU - Chen, Michelle B. AU - Chen, Yi-Jen PY - 2012 TI - A millimeter miss is as good as a thousand miles: The role of accurate target localization in lung stereotactic body radiation therapy JF - Journal of Thoracic Disease; Vol 4, No 2 (April 30, 2012): Journal of Thoracic Disease Y2 - 2012 KW - N2 - Surgical intervention with lobectomy and mediastinal lymph node dissection is considered the treatment of choice in early stage non-small cell lung cancer (NSCLC) (1). However, approximately 20-25% of patients with early stage NSCLC are poor surgical candidates for lobectomy because of concomitant severe cardiac or pulmonary co-morbidities. For these patients, conventional radiotherapy with 60 to 70 Gy delivered in 30-35 fractions over a 6-7-week period generally resulted in poor 20-40% 3-year and 10-30% 5-year survival rates (2,3). This inadequate tumor control is mainly due to the insufficient tumor dose that is limited by normal tissue toxicity and possible target-miss caused by tumor mobility. UR - https://jtd.amegroups.org/article/view/352