TY - JOUR AU - Luo, Qiaoling AU - Zheng, Zeguang AU - Cen, Huihong AU - Jiang, Mei AU - Chen, Qin PY - 2015 TI - A modified nebulization modality versus classical ultrasonic nebulization and oxygen-driven nebulization in facilitating airway clearance in patients with acute exacerbation of chronic obstructive pulmonary disease: a randomized controlled trial JF - Journal of Thoracic Disease; Vol 7, No 7 (July 30, 2015): Journal of Thoracic Disease Y2 - 2015 KW - N2 - Background: Ultrasonic nebulization (UN) and oxygen-driven nebulization (ON), two commonly used modalities for nebulization inhalation, are not ideally suitable for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 91 patients with AECOPD were randomized to three groups given different nebulization modalities: ON, UN, and ultrasonic nebulization with warming and oxygen (UNWO). The sputum clearance, lung function, changes in physiological measures such as peripheral oxygen saturation (SpO 2 ) and tolerance to these nebulization modalities were recorded and compared among the three groups. Results: The time to the first expectoration was shorter and the sputum volume was larger after UN and UNWO than after ON (both P 2 significantly increased (P 2 and dyspnea post-UNWO were significantly better than those post-UN (P 0.05). UNWO demonstrated significantly greater comfort and longer duration of nebulization than UN (P 0.05). Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF) decreased significantly after UNWO (P Conclusions: UNWO may promote expectoration of sputum with fewer adverse reactions and a higher level of comfort than simple UN and ON. Therefore, it can be used as an adjuvant therapy for AECOPD patients. UR - https://jtd.amegroups.org/article/view/4779