@article{JTD4825,
author = {Wenlong Shao and Hanzhang Chen and Jianxing He},
title = {The role of SOX-2 on the survival of patients with non-small cell lung cancer},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {7},
year = {2015},
keywords = {},
abstract = {Background: Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer death worldwide. Observational studies on the prognostic role of SOX-2 in non-small-cell lung cancer (NSCLC) are controversial.
Methods: To clarify the impact of SOX-2 in NSCLC survival, we performed this meta-analysis that included eligible studies. The combined hazard ratios and their corresponding 95% confidence intervals (95% CI) were calculated in terms of overall survival.
Results: A total of seven studies with 1,944 patients were evaluable for this meta-analysis. The studies were categorized by histology, disease stage and patient race. Our results suggested that SOX-2 overexpression had a favorable impact on survival of patients with NSCLC, the HR (95% CI) was 0.57 (0.48 to 0.65). However, highly significant heterogeneity was detected among these studies (I2=76.7%, P=0.000).
Conclusions: SOX-2 overexpression indicates a favorable prognosis for patients with NSCLC.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/4825}
}