%0 Journal Article %T The role of SOX-2 on the survival of patients with non-small cell lung cancer %A Shao, Wenlong %A Chen, Hanzhang %A He, Jianxing %J Journal of Thoracic Disease %D 2015 %B 2015 %9 %! The role of SOX-2 on the survival of patients with non-small cell lung cancer %K %X Background: Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer death worldwide. Observational studies on the prognostic role of SOX-2 in non-small-cell lung cancer (NSCLC) are controversial. Methods: To clarify the impact of SOX-2 in NSCLC survival, we performed this meta-analysis that included eligible studies. The combined hazard ratios and their corresponding 95% confidence intervals (95% CI) were calculated in terms of overall survival. Results: A total of seven studies with 1,944 patients were evaluable for this meta-analysis. The studies were categorized by histology, disease stage and patient race. Our results suggested that SOX-2 overexpression had a favorable impact on survival of patients with NSCLC, the HR (95% CI) was 0.57 (0.48 to 0.65). However, highly significant heterogeneity was detected among these studies (I 2 =76.7%, P=0.000). Conclusions: SOX-2 overexpression indicates a favorable prognosis for patients with NSCLC. %U https://jtd.amegroups.org/article/view/4825 %V 7 %N 7 %P 1113-1118 %@ 2077-6624