TY - JOUR AU - Liu, Qianwen AU - Gu, Zhitao AU - Yang, Fu AU - Fu, Jianhua AU - Shen, Yi AU - Wei, Yucheng AU - Tan, Lijie AU - Zhang, Peng AU - Han, Yongtao AU - Chen, Chun AU - Zhang, Renquan AU - Li, Yin AU - Chen, Keneng AU - Chen, Hezhong AU - Liu, Yongyu AU - Cui, Youbing AU - Wang, Yun AU - Pang, Liewen AU - Yu, Zhentao AU - Zhou, Xinming AU - Liu, Yangchun AU - Xiang, Jin AU - Liu, Yuan AU - Fang, Wentao AU - Research in Thymomas, Members of the Chinese Alliance for PY - 2016 TI - The role of postoperative radiotherapy for stage I/II/III thymic tumor—results of the ChART retrospective database JF - Journal of Thoracic Disease; Vol 8, No 4 (April 01, 2016): Journal of Thoracic Disease [Thymic Malignancy—Perspectives from the Chinese Alliance for Research in Thymomas (ChART)] Y2 - 2016 KW - N2 - Background: Postoperative radiotherapy (PORT) for thymic tumor is still controversial. The object of the study is to evaluate the role of PORT for stage I to III thymic tumors. Methods: The Chinese Alliance for Research in Thymomas (ChART) was searched for patients with stage I to III thymic tumors who underwent surgical resection without neoajuvant therapy between 1994 and 2012. Univariate and multivariate survival analyses were performed. Cox proportional hazard model was used to determine the hazard ratio for death. Result: From the ChART database, 1,546 stage I to III patients were identified. Among these patients, 649 (41.98%) received PORT. PORT was associated with gender, histological type (World Health Organization, WHO), thymectomy extent, resection status, Masaoka-Koga stage and adjuvant chemotherapy. The 5-year and 10-year overall survival (OS) rates and disease-free survival (DFS) rates for patients underwent surgery followed by PORT were 90% and 80%, 81% and 63%, comparing with 96% and 95%, 92% and 90% for patients underwent surgery alone (P=0.001, P Conclusions: The current retrospective study indicates that PORT after incomplete resection could improve OS and DFS for patients with stage I to III thymic tumors. However for those after complete resection, PORT does not seem to have any survival benefit on the whole. UR - https://jtd.amegroups.org/article/view/7010