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Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database

  
@article{JTD7011,
	author = {Guanghui Liang and Zhitao Gu and Yin Li and Jianhua Fu and Yi Shen and Yucheng Wei and Lijie Tan and Peng Zhang and Yongtao Han and Chun Chen and Renquan Zhang and Keneng Chen and Hezhong Chen and Yongyu Liu and Youbing Cui and Yun Wang and Liewen Pang and Zhentao Yu and Xinming Zhou and Yangchun Liu and Yuan Liu and Wentao Fang and Members of the Chinese Alliance for Research in Thymomas},
	title = {Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database},
	journal = {Journal of Thoracic Disease},
	volume = {8},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Background: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database.
Methods: From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis. Cumulative incidence of recurrence (CIR) was assessed in R0 patients. Overall survival (OS) was evaluated both in an R0 resected cohort, as well as in all patients (any R status). CIR and OS were first analyzed according to the Masaoka-Koga staging system. Then, they were compared using the new TNM staging proposal.
Results: Based on Masaoka-Koga staging system, significant difference was detected in CIR among all stages. However, no survival difference was revealed between stage I and II, or between stage II and III. Stage IV carried the highest risk of recurrence and worst survival. According to the new TNM staging proposal, CIR in T1a was significantly lower comparing to all other T categories (P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/7011}
}