TY - JOUR AU - Tsirigotis, Panagiotis AU - Chondropoulos, Spiros AU - Gkirkas, Konstantinos AU - Meletiadis, Josef AU - Dimopoulou, Ioanna PY - 2016 TI - Balanced control of both hyper and hypo-inflammatory phases as a new treatment paradigm in sepsis JF - Journal of Thoracic Disease; Vol 8, No 5 (May 01, 2016): Journal of Thoracic Disease Y2 - 2016 KW - N2 - The immune response of the host against invading pathogens is clinically manifested as sepsis. Sepsis is a complicated process characterized by distinct phases that usually occur in a sequential manner. The initial hyper-inflammation helps in elimination of the pathogen, but potentially may lead to excessive tissue injury. Hypo-inflammation helps in restoring immune homeostasis, but may lead to significant immune suppression and death from secondary infections if not appropriately controlled. Immune-modulating intervention in sepsis should be based on a balanced control of both the hyper and the hypo-inflammatory phase. UR - https://jtd.amegroups.org/article/view/7064