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Effect of parecoxib combined with thoracic epidural analgesia on pain after thoracotomy

	author = {Xiao-Min Ling and Fang Fang and Xiao-Guang Zhang and Ming Ding and Qiu-A-Xue Liu and Jing Cang},
	title = {Effect of parecoxib combined with thoracic epidural analgesia on pain after thoracotomy},
	journal = {Journal of Thoracic Disease},
	volume = {8},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Background: Thoracotomy results in severe postoperative pain potentially leading to chronic pain. We investigated the potential benefits of intravenous parecoxib on postoperative analgesia combined with thoracic epidural analgesia (TEA).
Methods: Eighty-six patients undergoing thoracic surgery were randomized into two groups. Patient-controlled epidural analgesia (PCEA) was used until chest tubes were removed. Patients received parecoxib (group P) or placebo (group C) intravenously just 0.5 h before the operation and every 12 h after operation for 3 days. The intensity of pain was measured by using a visual analogue scale (VAS) and recorded at 2, 4, 8, 24, 48, 72 h after operation. The valid number of PCA, the side effects and the overall satisfaction to analgesic therapy in 72 h were recorded. Venous blood samples were taken before operation, the 1st and 3rd day after operation for plasma cortisol, adrenocorticotropic hormone (ACTH), interleukin-6 and tumor necrosis factor-α level. The occurrence of residual pain was recorded using telephone questionnaire 2 and 12 months after surgery.
Results: Postoperative pain scores at rest and on coughing were significantly lower with the less valid count of PCA and greater patient satisfaction in group P (P0.05). The occurrence of residual pain were 25% and 51.2% separately in group P and C 3 months postoperatively (P},
	issn = {2077-6624},	url = {}