TY - JOUR AU - Grouse, Lawrence PY - 2013 TI - Can epigenetic changes cause COPD? Canaries in the coal mines JF - Journal of Thoracic Disease; Vol 5, No 1 (February 02, 2013): Journal of Thoracic Disease Y2 - 2013 KW - N2 - The relentless rise of COPD prevalence worldwide is a major cause of concern for affected patients and their physicians who have to diagnose and treat this difficult disease (1). COPD is believed to be caused by toxic inhalation (2), but the biological mechanism of COPD development is poorly understood, and different mechanisms may be involved with different clinical presentations of what we call COPD. Genetic analysis of COPD patients’ genomes indicates that the development of COPD is associated with many different genes (3). What biological regulatory mechanism could explain this process of causing COPD? UR - https://jtd.amegroups.org/article/view/845