Yugo Tanaka, MD

Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan


Minimal invasive surgery (VATS)
Extended surgery for thoracic malignancies

1996-2002 : Kobe University Graduate School of Medicine
2002 : M.D. Kobe University Graduate School of Medicine
2009 : Ph.D. Kobe University Graduate School of Medicine

Scientific & Medical Training

June, 2002 - May, 2003: Resident at Kobe University Hospital (General Surgery)
June, 2003 - May, 2005: Resident at National Hospital of Osaka (General Surgery)
June, 2005 – March, 2006: Resident at Kobe University Hospital (Respiratory surgery)
April, 2006 – Sep., 2009: Post-graduate Course and Senior Resident at Kobe University Graduate School of Medicine (oncology, tumor biology)
Oct., 2009- Jan., 2011: Post-doctoral position at Kobe University Graduate School of Medicine
May,2011- Aug., 2013: Research fellow at University of Pittsburgh Medical Center (Lung Transplantation)
Sep.,2013- Feb., 2016: Assistant professor at Kobe University Graduate School of Medicine (General Thoracic Surgery)
Mar.,2016- : Associate professor at Kobe University Graduate School of Medicine (General Thoracic Surgery)

Board Certification: 

2002- Japanese Medical License Registration
2007- Japanese Board of General Surgery
2010- Japanese Board of Thoracic Surgery

List of publications in impacted journals
1. Tanaka Y, Maniwa Y, Yoshimura M, Okita Y. Successful treatment of descending necrotizing mediastinitis. Gen Thorac Cardiovasc Surg 2007, 55: 366-369

2. Takata M, Maniwa Y, Doi T, Tanaka Y, Okada K, Nishio W, Ohbayashi C, Yoshimura M, Hayashi Y, Okita Y. Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity. Cell commun adhes 2007, 14: 157-167

3. Tanaka Y, Maniwa Y, Nishio W, Yoshimura M, Okita Y. The optimal timing to resect pulmonary metastasis. Eur J Cardiothorac Surg 2008, 33: 1135-1138

4. Tanaka Y, Nishio W, Hokka D, Kawamura S, Shimada E, Okumura S. Acute torsion of the left lower lobe caused by chronic traumatic hernia of the diaphragm. J Thorac Cardiovasc Surg. 2010, 139:e4-6.

5. Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M. Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. Cancer 2010, 116:896-902

6. Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci 2010, 101:1326-30.

7. Doi T, Maniwa Y, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y, Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M. MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell. Exp Mol Pathol. 2011;90(1):91-6.

8. Tane S, Tanaka Y*, Tauchi S, Uchino K, Nakai R, Yoshimura M. Radically resected epithelioid angiosarcoma that originated in the mediastinum. Gen Thorac Cardiovasc Surg. 2011;59(7):503-6

9. Wakahara T, Tanaka Y, Maniwa Y, Nishio W, Yoshimura M. Successful management of descending necrotizing mediastinitis by transthoracic drainage. Asian Cardiovasc Thorac Ann. 2011;19(3-4):228-31.

10. Tanaka Y, Ogawa H, Uchino K, Ohbayashi C, Maniwa Y, Nishio W, Nakao A, Yoshimura M. Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: A possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. J Thorac Cardiovasc Surg. 2013;145(3):839-46.

11. Sugimoto R, Tanaka Y, Noda K, Kawamura T, Toyoda Y, Billiar TR, McCurry KR, Nakao A. Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury. Eur J Cardiothorac Surg. 2012;42(6):1035-41

12. Tanaka Y (co-first author), Noda K, Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int. 2012;25(12):1213-22.

13. Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun. 2012;425(4):873-9.

14. Hyun Lim S, Lee S, Noda K, Kawamura T, Tanaka Y, Shigemura N, Nakao A, Toyoda Y. Adenosine injection prior to cardioplegia enhances preservation of senescent hearts in rat heterotopic heart transplantation. Eur J Cardiothorac Surg. 2013;43(6):1202-8.

15. Noda K, Shigemura N, Tanaka Y, Kawamura T, Hyun Lim S, Kokubo K, Billiar TR, Bermudez CA, Kobayashi H, Nakao A. A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Heart Lung Transplant. 2013;32(2):241-50.

16. Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol. 2013;304(10):L646-56.

17. Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW. Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling. Mol Cell Biol. 2014;34(4):653-63.

18. Noda K, Shigemura N, Tanaka Y, Bhama JK, D'Cunha J, Luketich JD, Bermudez CA. Successful prolonged ex vivo lung perfusion for graft preservation in rats. Eur J Cardiothorac Surg. 2014;45(3):e54-60.

19. Tanaka Y, Shigemura N, Noda K, Kawamura T, Isse K, Stolz DB, Bermudez CA. Optimal lung inflation techniques in a rat lung transplantation model: a revisit. Thorac Cardiovasc Surg. 2014;62(5):427-33.

20. Tane S, Nishio W, Ogawa H, Hokka D, Tane K, Tanaka Y, Tauchi S, Uchino K, Sakai Y, Ohbayashi C, Yoshimura M, Maniwa Y. Clinical significance of the 'not otherwise specified' subtype in candidates for resectable non-small cell lung cancer. Oncol Lett. 2014;8(3):1017-1024.

21. Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, Luketich JD, Bermudez CA. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. Transplantation. 2014;98(5):499-506.

22. Ogawa H, Tanaka Y, Koma YI, Hokka D, Tane S, Tauchi S, Uchino K, Yoshimura M, Maniwa Y. Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report. Oncol Lett. 2014;8(6):2621-2623.

23. Tanaka Y, Noda K, Isse K, Tobita K, Maniwa Y, Bhama JK, D'Cunha J, Bermudez CA, Luketich JD, Shigemura N. A novel dual ex vivo lung perfusion technique improves immediate outcomes in an experimental model of lung transplantation. Am J Transplant. 2015;15(5):1219-30.

24. Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Hokka D, Tane S, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Outcomes of segmentectomy for cT1bN0M0 lung adenocarcinoma and squamous cell carcinoma: a possible association with pathological invasion. Eur J Cardiothorac Surg. 2015;48(1):77-82.

25. Hokka D, Uchino K, Tane K, Ogawa H, Tane S, Tanaka Y, Tauchi S, Nishio W, Yoshimura M, Maniwa Y. Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma. Mol Clin Oncol. 2015;3(1):244-248.

26. Tomono A, Nakamura T, Otowa Y, Imanishi T, Tanaka Y, Maniwa Y, Kakeji Y. A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction. Ann Thorac Cardiovasc Surg. 2015;21(3):289-92.

27. Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings. Interact Cardiovasc Thorac Surg. 2015;21(1):34-9.

28. Tane S, Nishio W, Okuma H, Ogawa H, Hokka D, Tane K, Tanaka Y, Uchino K, Yoshimura M, Maniwa Y. Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer. Asian Cardiovasc Thorac Ann. 2015;23(8):950-7.

29. Hokka D, Ogawa H, Tane S, Tanaka Y, Tauchi S, Maniwa Y. Ruptured thymoma causing a hemothorax: A case report. Oncol Lett. 2015;10(3):1810-1812.

30. Tanaka Y, Tane S, Hokka D, Ogawa H, Maniwa Y. The Use of Oxidized Regenerated Cellulose for Video-Assisted Thoracic Surgery. Ann Thorac Surg. 2016;101(2):786-8.

31. Tauchi S, Sakai Y, Fujimoto S, Ogawa H, Tane S, Hokka D, Tanaka Y, Nishio W, Yoshimura M, Yanagita E, Itoh T, Hayashi Y, Maniwa Y. Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections. Eur J Cardiothorac Surg. 2016;50(4):758-764.

32. Tachihara M, Tanaka Y, Zen Y, Nishimura Y. The Notable Appearance of Pulmonary Artery Intimal Sarcoma on Positron Emission Tomography (PET)/CT. Intern Med. 2017; 56(21):2953-2954.

33. Tanaka Y, Hokka D, Ogawa H, Shimizu N, Inoue T, Tanaka H, Okita Y, Maniwa Y. Surgery for malignant lesions of the chest which extensively involved the mediastinum, lung, and heart. Gen Thorac Cardiovasc Surg. 2017;65(7):365-373.