Mingyao Liu, MD, MSc
Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Dr. Mingyao Liu is a Professor of Surgery and Director of Institute of Medical Science at the Faculty of Medicine, University of Toronto. He is a Senior Scientist and Head of Respiratory and Critical Care Research at the Toronto General Research Institute, University Health Network.
University of Toronto Lung Transplantation Program and Latner Thoracic Surgery Research Laboratories are one of the leading groups in clinical practice and translational research in lung transplantation worldwide. Dr. Liu is one of the co-founder of this team. His major research is to study the cellular and molecular mechanisms of acute lung injury, especially in lung transplantation. He demonstrated that lung epithelial cells as a source of cytokines in inflammatory response, intracellular signal transduction pathways as therapeutic targets, and roles of multiple cell death pathways in acute lung injury. He has developed nano-particle based drug delivery systems. A drug discovery/delivery pipeline has been developed in the Toronto team, including cell culture for high throughput screening for therapeutic targets, mouse/rat lung transplant models for in vivo testing, and pig lung transplant and ex vivo lung perfusion system for pre-clinical trials.
His lab also discovered a novel adaptor protein, XB130, for signal transduction, and demonstrated its role in cell survival, proliferation, migration and regulation of gene expression. Using xb130 knock mice, they are studying the role of XB130 in lung injury and repair. Dr. Liu has published over 260 peer-reviewed research articles (Google Scholar citation 11176, H-index 57, i10-index 169). He has received a number of research awards, including Queen Elizabeth II Diamond Jubilee Medal.Dr. Liu has taken several academic administrative roles in the University of Toronto, including Graduate Coordinator, Associate Director/Interim Director at the Institute of Medical Science, Associate Dean of Life Sciences of the School of Graduate Studies, and Director of International Research Relations, at the Faculty of Medicine.