Jerome M Reich, MD, FCCP
Earle A Chiles Research Institute
New York University, BA, 1958
State U. New York, College of Medicine, Syracuse 1962.
University of Utah, internship, residency and pulmonary fellowship completed 1969
Retired from clinical practice of pulmonary medicine. Affiliated with Earle A Chiles Research Institute, Portland, Oregon
Past president, Oregon Thoracic Society
Investigative interest: 119 publications as sole or lead author:
Sarcoidosis. Positive predictive value of a radiograph demonstrating bilateral hilar adenopathy exceeds 99.95%. Sarcoidosis is an etiologically heterogeneous syndrome. Overall favorable prognosis of conservatively managed sarcoidosis (mortality ≈ 0.5%) vs. tertiary care figures of 5-10%. Corticosteroid therapy in early sarcoidosis, by impairing resolution, has a net adverse long-term effect Unifying view that sarcoidosis represents an immunologic fallback response due to inefficient cell-mediated immunity.
Pulmonary disease due to M. avium complex. Characterized primary MAC disease and proposed a mechanism for its occurrence. Characterized and named a novel entity—Lady Windermere Syndrome—and proposed a novel pathogenetic mechanism for its development—volitional cough suppression. Identified the nexus of differential African-American granulomatous susceptibilities mediated by NRAMP: sarcoidosis and M. tuberculosis susceptibility; M. avium-intracellulare resistance.
Lung cancer screening. The paradox of a markedly increased lung cancer survival in the screened cohorts accompanied by an increase in their mortality vs. controls in chest radiographic (CR) screening explained by a combination of overdiagnosis and long-term reduction in life expectancy due to surgical loss of pulmonary reserve. Quantified overdiagnosis as the excess of cases in the intervention cohort after long-term follow-up, estimated at 24% and 42% respectively for CR and CT screening. Lobectomy imposes a 41% longer-term, disease-free, survival reduction. An exponential model of lung cancer growth demonstrates that a large majority of minute lung cancers would survive without treatment for more than five-years.
Fibrosing alveolitis and extrinsic allergic alveolitis. The neutrophilic lavage findings in persons with diffuse interstitial fibrosis reflects sequestration of neutrophils in bronchiolectatic regions of the lung (not neutrophilic alveolitis).