Kazuaki Takabe, MD, PhD, FACS

Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA

Professor of Oncology, Alfiero Foundation Chair and Clinical Chief of Breast Surgery, Leader of Breast Program and Breast Disease Site, Breast Oncology Fellowship Program Director, Roswell Park Cancer Institute, New York, USA; Professor of Surgery, Division of Surgical Oncology, Department of Surgery, University at Buffalo, The State University of New York, Jacobs School of Medicine and Biomedical Sciences, New York, USA

Dr. Takabe is a Surgeon-Scientist who conducts both basic and clinical research in a broad range of topics including Breast, Gastrointestinal tract including the Liver, and Surgery. His clinical practice is general surgical oncology with a focus on breast surgery. He is Principal Investigator of NIH-R01 grant (R01CA160688) and Susan G. Komen Investigator Initiated Research Award (IIR12222224). He serves as a member of the Editorial Board in 8 peer-reviewed medical journals. His main basic research interest is on the roles of Sphingosine-1 phosphate (S1P) in cancer, which was discovered to be a novel lipid signaling molecule. Dr. Takabe’s laboratory discovered the mechanism of how S1P, which is generated inside breast cancer cells, is exported outside to perform “inside-out” signaling, and reported the role of S1P in inflammation, lymphangiogenesis and metastasis. Dr. Takabe has published more than 60 peer-reviewed manuscripts on both basic and clinical topics in journals such as Cancer Cell, Pharmacological Reviews, PNAS, Hepatology, Cancer Research, FASEB Journal, Brest Cancer Research and Treatment, Surgery, and Gland Surgery.