Prevention of organ dysfunction in septic shock: still looking for an effective treatment

Giovanni Landoni, Alessandro Belletti, Alessandro Putzu, Alberto Zangrillo


Severe sepsis and septic shock are currently a major medical issue all over the world. Sepsis has a worldwide estimated incidence of up to 19 million per year (1) and accounts for more than one third of intensive care unit (ICU) admissions (2).
Furthermore, reported incidence of sepsis has continuously risen in recent years (3). Despite improvement in patients’ care, mortality remains high (2-4), accounting for 5.3 million of deaths every year (5), even if a decrease in mortality rates is evident throughout the last years (3). As a consequence, identifying treatment strategies aimed at improving survival of septic patients is a primary goal of research in the field critical care medicine.

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