Hydrocortisone in septic shock: all the questions answered?

Josef Briegel, Volker Huge, Patrick Möhnle

Abstract

Regarding sepsis, a fundamental change in the understanding of the pathophysiology has evolved in the last five decades, from the early concepts of an overwhelming inflammation to disease models increasingly based on the role of a dysregulated host immune response (1). Consequently, the first therapeutic attempts to use corticosteroids in sepsis applied high doses in order to effectively suppress hyper-inflammation.