Original Article

Characteristics and survival difference of clinical tumor size 0 extensive-stage small cell lung cancer with different metastasis pattern

Haiyong Wang, Xiao Han, Jun Guo, Zhehai Wang


Background: Few studies were focused on the characteristics and survival prognosis of clinical tumor size 0 (cT0) extensive-stage small cell lung cancer (ES-SCLC) patients with distant metastasis.
Methods: The proper patients were screened based on the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2013. Chi-square test was used to analyze the characteristics of cT0 stage. The risk factors on cT0 stage were analyzed by Logistic regression model. The survival difference was compared by the Log rank test. The prognostic factors on survival were analyzed by univariate and multivariate Cox regression model.
Results: Only 1.2% of patients were diagnosed at cT0 stage. Clinical nodal status 0 (cN0) stage, no bone metastasis and no lung metastasis were all risk factors on cT0 stage. The patients at cT0 stage had better cancer specific survival (CSS) benefit (P=0.011). The cT0 stage was also an independent prognostic factor on CSS (P=0.018).
Conclusions: The patients at cT0 stage was a different subgroup compared with the patients at cT1–4 stage for ES-SCLC patients with distant metastasis.

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