Insights from advancements and pathbreaking research on the minimally invasive treatment of atrial fibrillation
Review Article on Minimally Invasive Cardiac Surgery

Insights from advancements and pathbreaking research on the minimally invasive treatment of atrial fibrillation

Anna Witkowska^, Piotr Suwalski^

Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, Centre of Medical Postgraduate Education, Warsaw, Poland

Contributions: (I) Conception and design: P Suwalski; (II) Administrative support: All authors; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: A Witkowska; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

^ORCID: Piotr Suwalski, 0000-0003-2670-4164; Anna Witkowska, 0000-0001-8188-0422.

Correspondence to: Anna Witkowska. Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, Centre of Medical Postgraduate Education, Warsaw, Poland. Email:

Abstract: Atrial fibrillation (AF) remains the most common cardiac arrhythmia with increasing prevalence in developed and aging countries. Pharmacological antiarrhythmic therapy has low effectiveness and is limited by its toxicity. Developed in 1987 by James Cox surgical ablation of AF called MAZE procedure was very effective, but due to its invasiveness and complexity was not widely adopted. Landmark research done by Haissaguerre in 1998 initiated a new approach for treatment namely percutaneous catheter ablation, which remains a class I/A indication in symptomatic paroxysmal AF refractory to optimal medical therapy. However, its efficacy in patients with persistent atrial fibrillation (PSAF) is far from satisfactory. Recent advancements in devices and techniques of minimally invasive surgical ablation show very good results in the treatment of PSAF. Current guidelines equate surgical with catheter ablation within the scope of efficacy indicating that both may be considered as an effective and safe treatment option for patients with persistent forms of arrhythmia. The higher efficacy of surgical ablation was confirmed at a 7-year follow-up of FAST trial with recurrence rate as high as 87% in catheter arm compared with 56% in thoracoscopic ablation arm. A new concept of the invasive treatment of AF consisting of combined surgical (epicardial) and electrophysiological (endocardial) was introduced in 2009. Recently experts’ opinions and published data suggest that the proper hybrid treatment consisting of a planned combination of surgical and catheter ablation may give even better results. One of the most invaluable benefits of surgical ablations is the possibility of concomitant occlusion of the left atrial appendage. Recently good results have been reported for the novel epicardial clip for closing the left atrial appendage, which is placed in the deployment loop on a disposable holder.

Keywords: Ablation; atrial fibrillation (AF); minimally invasive surgery; hybrid approach;

Submitted May 10, 2020. Accepted for publication Oct 14, 2020.

doi: 10.21037/jtd-20-1876


Atrial fibrillation (AF) is the most common cardiac arrhythmia with increasing prevalence in developed and aging countries. It occurs in 3% of the population over 20-year and even 9% in those over 80-year. Estimates anticipate that by 2030, 14–17 million patients in the European Union will develop AF and 120,000–215,000 patients will be diagnosed every year (1). An increasing lifespan with the advancement in medical care may significantly contribute to a greater incidence of AF, especially in cohort with hypertension, structural heart disease, obesity, diabetes, or endocrinological disorders. The main issue in AF treatment is the adverse events as it is associated with a 5-fold increased risk of thromboembolic events, 2-fold increased risk of myocardial infarction, repeated hospitalizations, and worse quality of life (1-4). These factors raise mortality and the economic and social cost of care of this group of patients (1,5-7).

Pharmacological antiarrhythmic therapy has low effectiveness and is limited by its toxicity, and recently there were no significant improvements in this field (8,9). The introduction of the novel oral anticoagulants (NOACs) improved compliance and safety of the therapy mainly due to a reduction in hemorrhagic complications (1,10). Nevertheless, the most important measure in stroke prevention remains the stable sinus rhythm restoration.

Developed in 1987 by James Cox surgical ablation of AF called MAZE procedure was very effective, but due to its invasiveness and complexity was not widely adopted (11,12). In subsequent years it was modified by its author in terms of lesions sets establishing the MAZE III procedure, which to this very day is the gold standard in surgical AF ablation (13). Further evolvement changed the way to create a transmural scar and enable minimalization of surgical access, which universalized and popularized the procedure (3,14). As a new standard regarded is the endocardial biatrial lesion set performed with bipolar radiofrequency and/or cryoablation through right minithoracotomy called MAZE IV (15,16). Recently surgical ablation in patients with arrhythmia undergoing other cardiac operations is recommended in class IIaA and the scars should be performed with radiofrequency energy or cryothermy (3). Landmark research done by Haissaguerre in 1998 initiated a new approach for the treatment and gave the rudiments of percutaneous catheter ablation (17) which is now the basic treatment for paroxysmal AF refractory to optimal medical therapy (class IA indication) (1). However, for stand-alone persistent forms of atrial fibrillation (PSAF) results of this treatment remain far from satisfactory (18-20). In 2019 Berger et al. published a meta-analysis of 60 papers presenting results of invasive treatment of persistent AF published from 2006 to 2018. The analysis showed that surgical minimally invasive procedures have a higher success rate in sinus rhythm restoration, however with more adverse events (21). Recent advancements in techniques of minimally invasive surgical ablation show very good efficacy in the treatment of PSAF (22). In guidelines published by the European Society of Cardiology in 2016 surgical and catheter ablation should be considered as a therapeutic option for persistent and long-standing persistent AF (IIaC) indicating that both types of treatment are effective and safe (1,19,23,24). Moreover, published data indicate that success rates of catheter procedures decline with a given time and are lower than 50% in 1 year (25). Frequently patients undergo multiple ablations what increases the exposition to radiation, risk of complications, and healthcare costs. Surgical ablation offers a higher success rate, but its higher invasiveness, chest incisions, and dissections around the heart limit widespread acceptance. In the last update of the guidelines of management of AF published by the European Society of Cardiology (ESC) and by the Society of Thoracic Surgeons recommend that surgical ablation as a stand-alone procedure should be considered in patients who have failed a previous catheter ablation (IIaB) or with refractory to AAD therapy symptomatic arrhythmia as a patient choice in the level of evidence IIaC (1,3). However, the surgical procedure should be performed with minimally invasive techniques in an experienced center (IIaC) (1).

The key concepts

J. Cox proposed the concept of surgical ablation based on the surgically made pathway for the electric impulse from the sinus node to the atrioventricular node (12). Those pathways were made by cutting and sewing the muscle of the left and right atria, that is why it is called “the Maze” procedure. Although extremely effective, it is technically challenging while requires a full sternotomy, cardiopulmonary bypass with aortic cross-clamping, and cardiac arrest. The main complications, that occurred quite frequently were bleeding and complete atrioventricular block. Advancement in minimally invasive techniques (26,27) allowed for the reappearance of the surgical ablation with “maze-pattern” lines through a minimal surgical incision (28). The next step was the introduction of the off-pump epicardial techniques, however, the main problem was the creation of transmural lesions and effectiveness in sinus rhythm restoration. Numerous energy sources have been tested, but recently only radiofrequency and cryothermy confirmed the effectiveness and are acceptable (3). Constraints associated with limited access impose modifications of the original MAZE lesion set, however, the essentials of the concept remained the same: (I) pulmonary vein isolation; (II) modification of the substrate; (III) addressing the left atrial appendage (LAA) whenever possible.

This review aims to present medical professionals emerging options of treatment of stand-alone PSAF and long-standing PSAF which benefits from new minimally invasive techniques, namely:

  • Stand-alone surgical epicardial ablation with bipolar radiofrequency energy and exclusion of the left atrial appendage via thoracoscopic access;
  • Hybrid approach as a planned strategy of minimally invasive surgical ablation followed by transcatheter electrophysiological control after the blanking period
  • The hybrid convergent procedure with connected epicardial and endocardial ablation for complete extended lesion pattern.

The stand-alone minimally invasive surgical procedure

The first step towards reducing the invasiveness of the surgical approach was done by Randal Wolf in 2005. He performed the off-pump epicardial isolation of the right and left pulmonary veins through bilateral mini-thoracotomies with a bipolar radiofrequency device (29). The “Wolf procedure” included bilateral antrum isolation with partial cardiac denervation. The next step was a totally endoscopic approach that enforced the oversimplification of the concept of a “box-lesion” as a single circular lesion around all four pulmonary veins including the posterior wall of the LA. The lesion was created with unipolar radiofrequency devices with an ablating part placed on the inner side of a single tube. (30,31). However, separating the pericardial reflections or superior vena cava (SCV) from the right pulmonary artery requires endoscopic skills and may lead to laceration and bleeding.

This procedure became widely accepted, but in longer observation effectiveness in SR restoration was moderate and it was dedicated mainly for the treatment of paroxysmal AF which was already taken over by less invasive percutaneous techniques. Nevertheless, the idea of a surgical “box-lesion” was further developed and in 2011 Muneretto et al. presented a partly hybrid approach using an RF device (Estech, Cobra Adhere XL, AtriCure, Inc., West Chester, Ohio, USA) to create a primary “box-lesion” via right-sided thoracoscopic access with concomitant implantation of a continuous monitoring rhythm device (Reveal XT; Medtronic, Minneapolis, MN USA) (22). Other modification named “Brescia Lesion Set” involved the addition of three lesions on the lateral wall of the right atrium. This approach resulted in a success rate exciding 85%, and additionally, as an emerging conception of hybrid treatment in patients with recurrences percutaneous catheter-based endocardial ablation was performed (14,32).

At the same time, Wolf’s procedure was modified within the scope of the lesion pattern and converted to the video-assisted totally endoscopic ablation. The extent of the ablation was broadened and included not only pulmonary veins isolation but also the line to the mitral or aortic trigones, ganglionated plexi ablation, the obliteration of ligament of Marshall, and left atrial appendage exclusion (33). Lesions could be done through thoracoscopic access with dedicated bipolar devices manufactured by AtriCure (AtriCure, Inc., West Chester, Ohio, USA). This system was also used in the surgical arm of the Atrial Fibrillation Catheter Ablation Versus Surgical Ablation Treatment (FAST) (34,35).

The FAST trial

The Atrial Fibrillation Catheter Ablation Versus Surgical Ablation Treatment trial was the first prospective randomized clinical trial conducted to compare catheter and surgical ablation (34). The study included 125 patients randomized into two treatment arms. The higher efficacy of surgical ablation was confirmed at 1 year (65% vs. 36%) as well as in a longer, mean 7-year follow-up with recurrence rate as high as 87% in catheter arm compared with 56% in thoracoscopic ablation arm (35). It is noteworthy that 23% of included patients had paroxysmal AF, and the continuation of AAD did not influence the results (78% in surgical vs. 42% in catheter arm). This was the first systemic comparison which showed superior results of surgical ablation to catheter one in receiving freedom from left atrial arrhythmias in long-term observation. Although observed periprocedural adverse event rate was significantly higher in the surgical arm, most of them were minor and the composite endpoint of mortality, myocardial infarction, or cerebrovascular event was equal in both arms through all follow-up (34,35). Regrettably, the most remembered by the public was the number of periprocedural complications, not the success rate.

In a published in 2016 meta-analysis Phan et al. confirmed better results of surgical minimally invasive ablation for sinus rhythm restoration in comparison with catheter ablation (36). For patients with paroxysmal AF success rate was 82% for surgical procedure vs. 62.5% for catheter one and in patients with persistent AF the results were 74.4% vs. 51.1% respectively in 12-month follow up (36). Recently there is an ongoing new randomized international multicenter trial comparing interventional treatment strategies in symptomatic patients with drug-refractory PSAF—CEASE-AF. The study has two arms—one is a multiple catheter ablation and the second is a hybrid approach with totally thoracoscopic surgical ablation with left atrial appendage closing followed by electrophysiological examination 90–180 days later. In the time of publishing this article, the study was during the interim analysis.

The totally thoracoscopic ablation procedure

The totally thoracoscopic ablation of AF is an off-pump procedure employing bilateral access and extended lesion set which include PVI, connecting lines on the posterior wall of LA, a line to the non-coronary aortic sinus („trigonal” line) recently replaced with a line from left PVI to the LAA, the ganglionated plexi (GP) ablation, and the LAA exclusion (Figure 1). The procedure is performed with AtriCure (AtriCure, Inc., West Chester, Ohio, USA) system utilizing the bipolar radiofrequency energy.

Figure 1 Left atrial lesion set for totally thoracoscopic ablation. The “Dallas” lesion. Courtesy: AtriCure.

The procedure was described in detail previously (37). In summary, trans-esophageal echocardiography is mandatory to rule out thromboembolic material in the left atrium. Thoracoscopic ports are placed through the 4th and 6th intercostal spaces in the midaxillary line. The working space is created with CO2 insufflation. First, the right-sided ablation is performed. The pulmonary veins and Waterstone’s Groove (on the right side) are exposed, the oblique and transverse pericardial sinuses are opened and pulmonary veins are encircled with the AtriCure Lumitip Dissector (AtriCure, Inc., West Chester, Ohio, USA) to guide Isolator Synergy Clamp (AtriCure, Inc., West Chester, Ohio, USA) (Figure 2), the proper ablating device for PVI at the antrum of the veins (18). On the right side the identification and ablation of GP are performed (Figure 3) and from both sides, linear lesions with Isolator Linear Pen (AtriCure, Inc., West Chester, Ohio, USA) on the posterior wall of the left atrium connecting the right and left PVI lines. On the left side also the ligament of Marshall is addressed and left atrial appendage is excluded with a GI stapler or with dedicated epicardial clip AtriClip® PRO LAA Exclusion System (Atriclip, Atricure, Dayton, OH, USA). The obligatory endpoint of each ablation is the confirmation of bidirectional acute conduction block across pulmonary veins isolation defined as the absence of sensed atrial potentials in the PVs and pacing conduction to the atria from PVs in patients in sinus rhythm.

Figure 2 Standalone surgical ablation of AF. Isolator Synergy Clamps are placed around the right pulmonary veins. The view from the endoscopic camera.
Figure 3 Standalone surgical ablation of AF. Clearly visible lesion separating right pulmonary veins from the left atrium. Ablation of ganglionated plexi with the unipolar device.

The hybrid approach

A hybrid approach to AF treatment as defined by the ESC in 2016 guidelines comprises only combination antiarrhythmic drug therapy with catheter ablation (1). Such an understanding has quite a lot of drawbacks, as results are still far from satisfactory and patients do not avoid adverse events of AAD. Recently even more experts’ opinions and published data suggest that the proper hybrid treatment should consist of a planned combination of surgical and catheter ablation. Such an approach for the first time reported Mahapatra et al. presenting the result of a sequential hybrid procedure in patients with PASF or LPASF and enlarged left atrium (LA size: 52 mm) who already failed at least one percutaneous catheter ablation (38). The analyzed procedure consisted of thoracoscopic epicardial surgical ablation with PVs and SVC isolation, box lesions, mitral line, ganglionated plexi ablation, ablation of the ligament of Marshal, and LAA exclusion, followed by an endocardial EP procedure 4.3±1.3 days later. In their study, 86.7% of the patients were free of any atrial arrhythmias without AAD in a mean follow-up of 20.7±4.5 months (38).

Other publications also affirm better results of combined treatment (32,39). The explanation may be found in the paper of Nanthakumar et al. As minimally invasive or thoracoscopic surgical ablations are mainly designed to create a full set of transmural lesions, they showed that recurrences are still present and conduction across the intraoperatively confirmed lines occurs in follow-up (40). Bulava et al. prospectively performed endocardial electrophysiological mapping at 94 (±30) days after epicardial radiofrequency ablation. Although 75.7% of patients were in stable sinus rhythm and 61.4% off AAD, they found complete lines around PVI in only 68.6% and lines on the posterior left atrial wall were complete in only 22.9% of cases (41). Termination of conduction was achieved using focal applications providing that in 82.9% of patients arrhythmia was not induced, what shows that the gaps were focal. This paper provides very important insight into the underbellies of epicardial procedure giving the basis for improvement in equipment and surgical technique. Also, Bisleri et al. reported better results when the electrophysiological examination is scheduled a few weeks after thoracoscopic ablation. In his cohort sinus rhythm restoration was augmented from 82.9% to 92.6% after focal catheter ablation (32).

Better results of hybrid treatment were recently published by Asmundis et al. Their approach consisted of totally thoracoscopic bilateral RF ablation followed by simultaneous catheter ablation. However, the success rate after the initial simultaneous hybrid procedure was 67.2% at a mean follow-up of 23.1 (±14.1) months, the overall freedom from AF including the following redo RF procedures was as high as 79.7% (42). The timing and sequence of the stages of the hybrid procedure remains a matter of debate. Doing the whole procedure during one session lessens the risk of repeated hospitalization, anesthesia, and procedure at the price of prolonged procedural time. Whereas separating the procedure in two stages with a 1 to 3 months gap allows the epicardial lesions to heal and stabilize, what might uncover more conduction gaps and warrants the overall efficacy (42). Also, two previous studies on sequential hybrid ablation reported a high overall success rate of 87% and 91.6% without AAD, suggesting that maturation of the lesion might be warranted to ensure better outcomes (32,33). These encouraging observations were the background of an ongoing randomized multicenter trial CEASE-AF described above.

The modification of the abovementioned techniques is a multidisciplinary procedure merging the surgical thoracoscopic epicardial ablation with electrophysiological endocardial completing of lines. The reported results of this combined approach are very promising, in particular in patients with LSPAF (22,43).

The convergent procedure

The idea of joint ablation procedure involving both surgeon (epicardial ablation) and electrophysiologist (endocardial ablation) was initiated in 2009 and is now referred to as the convergent procedure. It has been widely adopted with favorable outcomes published by many centers and now the concept “Convergent Approach/Procedure” defines the cooperation of electrophysiologists and cardiac surgeons as the AF-Heart Team in the complex treatment of AF (44-46). The convergent procedure was described previously (26,37). As in every rhythm control measure in AF treatment preceding TEE is mandatory. The classical approach is trans-diaphragmatic with standard laparoscopic techniques. Through a small incision below the xiphoid process in the midline abdomen, the central tendon of the diaphragm is exposed for the Subtle Cannula to be inserted into the pericardium. The cannula is the passage for the endoscope and ablation probe EPi-Sense Coagulation Device (AtriCure, Inc., West Chester, Ohio, USA; previously nContact Surgical Inc.). The ablating device utilizes unipolar radiofrequency energy which is regulated by an algorithm based on tissue impedance. This part of the procedure protocol implies a comprehensive epicardial ablation pattern including isolation of the posterior wall of the LA, posterior and anterior sides of both pulmonary veins, ganglionated plexi ablation, and in case of favorable anatomy also ablation of the ligament of Marshall (26,37). However, due to the anatomy of pericardial reflections, transdiaphragmatic access does not allow to reach superior aspects of both PVs and the inferior region of the right pulmonary vein. That is why to complete circumvention of the pulmonary veins the second part—endocardial ablation is mandatory. The use of an electro-anatomical mapping system gives the possibility to perform the isopotential map of the LA and identification and ablation of all areas with persistent conductivity. At the end of the whole procedure, electrical isolation is verified by rapid pacing. The patient may be extubated on the operating table and discharged home on postoperative day 2–4 (26,37). The drawback of the convergent procedure is the utilization of fluoroscopic guidance for both endo and epicardial stages to visualize the relation between the ablating electrode and the esophagus (26).

The Convergent Procedure is widely performed with good results and safety profile in published data (37,45,47,48). The one-year effectiveness in sinus rhythm restoration is reported from 79% to 95% of treated patients (37). The complication rate varies between the centers and ranges from none to 11% with the most frequently reported being mild pericarditis. Less frequent were stroke and transient ischemic attack (TIA) within the first 30 days, esophageal fistulas, bleeding, and tamponade (37,49). The very important point is that those two procedures remain unchanged in their design and performance. The differences occur in timing between them, which may vary from ablation done sequentially during the same procedure to 7 to 21 days apart (37).

Presently new subxiphoid access to pericardium directly under the sternum is investigated for feasibility and efficacy. The skin incision is similar to the one seen in convergent procedure, however, the abdominal cavity is not opened and the pericardial sack is reached above the diaphragm (47).

Rhythm monitoring

The novel guidelines of surgical treatment of AF published by the Society of Thoracic Surgeons in 2017 recommends rhythm monitoring 3, 6, 9, 12, and 24 months after the procedures, preferably with 24-hour Holter monitoring (3). The recurrence is defined as any atrial arrhythmia longer than 30 seconds (50). Although in guidelines of the European Society of Cardiology there is no clear information on how patients should be monitored, especially after invasive treatment, it is recommended to perform longer period monitoring, such as a 7-day Holter or implantable loop recorders rather than sole 24-hour Holter. In the expert consensus of the International Society for Holter and Noninvasive Electrocardiology (ISHNE) and Heart Rhythm Society (HRS) published in 2017 rhythm monitoring is mandatory after ablation including ECG recordings at every visit (51). For patients with paroxysmal AF 24-hour Holter should be performed at 1 year, also event recording continuously or at the time of symptoms from 3 to 12 months following ablation may be considered. For persistent AF 24-hour Holter monitoring is recommended each 6 months and additionally event-driven ECG monitoring (51). Holter monitoring is the most common way form rhythm assessment, however, it is limited by a relatively brief duration (52). However, they allow the registration of only one lead and as they have limited storage capability (generally less than 1 hour) retain only the information pertaining to relevant arrhythmias that are automatically detected. This may yield some arrhythmias to be missed and render the interpretation of the ECG difficult (52). Another interesting option is patient-activated event and loop recorders which can be used for several weeks and allows to capture the arrhythmia during symptomatic events (51,52).

LAA exclusion

One of the most invaluable benefits of surgical ablations is the possibility of concomitant occlusion of the left atrial appendage. Based on results from randomized studies mainly on transcatheter devices, the European Society of Cardiology recommends the closure of LAA in the prevention of thromboembolic events in class IIbB (1). As surgical endocardial closure with the suture showed a remarkably high rate of recanalization in follow up it is strictly recommended to use dedicated surgical devices (53). There are few devices for epicardial LAA closure which may be used via classical or minimally invasive procedures. The totally thoracoscopic access via the chest wall gives straightforward access to the left atrial appendage. After opening the pericardium above and parallel to the phrenic nerve its feasible to safely exclude the appendage under direct vision. For this purpose, it is possible to use endoscopic Endo-GIA stapler with the reloads Tri-Staple (Medtronic, Minneapolis, USA), which shows very good properties in hermetic tissue squeezing with a sealed stapling line. However, due to the fact that the appendage is cut off there exists the risk of tear and life-threatening bleeding (54). Recently good results have been reported for the novel device AtriClip®PRO1 and AtriClip®PRO2 LAA Exclusion System (AtriClip, Atricure, Dayton, OH, USA) consisting of an automatic closing clip set on the deployment loop on a disposable holder (Figure 4). The clip is constructed from parallel titanium crossbars that equalize the force over the tissue trabeculations of the LAA. This ensures a sealed line at the base of the LAA orifice (55). Before final deployment, the clip can be reopened and adjusted in case of an unsatisfactory result. The family of AtriClip Devices includes the newest open-ended AtriClip PRO-V device for thoracoscopic delivery. Although during convergent ablation the LAA may be visualized with pericardioscopy, its occlusion via transdiaphragmatic access is impossible due to limited working space within the tubular cannula. However, it is possible to adopt minimally invasive thoracoscopic techniques and close the LAA through the left pleura. From this side, it is also possible to perform ablation on the anterior and superior parts of the left pulmonary veins, the ligament of Marshall, and the roof of the left atrium under direct vision. An alternative is percutaneous closure of LAA with either endocardial or hybrid devices (37).

Figure 4 Totally thoracoscopic left atrial appendage occlusion with AtriClip PRO 2. The visible delivery system being withdrawn after clip release at the base of LAA. The view from the endoscopic camera.

Final remarks

Intensive advancement in minimally invasive surgical ablation techniques paved the way to overcome the main obstacle for widespread acceptance of this treatment of AF. The high rate of stable sinus rhythm restoration in a few years follow-up after classical techniques are now reproduced with safer and more surgeon friendly energies and devices. There is increasing number of data pointing out a significant decline in the effectiveness of catheter ablation of PSAF in longer than the one-year follow-up. And as increasing number of patients require multiple catheter procedures there is a vast territory for minimally invasive, safe, and effective surgical treatment options for the most demanding patients. When coupled with transcatheter procedures in hybrid strategies they have the potential to reach better outcomes and patient satisfaction, along with the appropriate use of limited institutional resources.


Funding: None.


Provenance and Peer Review: This article was commissioned by the Guest Editors (Jason Ali and Yasir Abu-Omar) for the series “Minimally Invasive Cardiac Surgery” published in Journal of Thoracic Disease. The article has undergone external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at The series “Minimally Invasive Cardiac Surgery” was commissioned by the editorial office without any funding or sponsorship. PS reports personal fees from Atricure, outside the submitted work. AW reports other from AtriCure, outside the submitted work. The authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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Cite this article as: Witkowska A, Suwalski P. Insights from advancements and pathbreaking research on the minimally invasive treatment of atrial fibrillation. J Thorac Dis 2021;13(3):2000-2009. doi: 10.21037/jtd-20-1876