AB 60. Nitric oxide measurements in lung cancer
Abstract

AB 60. Nitric oxide measurements in lung cancer

Anastasios Kallianos1, Aggeliki Rapti1, Sotirios Tsimpoukis2, Andriani Charpidou2, Ahimastos Apostolos2, Paul Zarogoulidis3,4, Konstantinos Porpodis3, Dionisios Spyratos3, Georgia Trakada5, Konstantinos Zarogoulidis3, Konstantinos Syrigos2

12nd Pulmonary Clinic of the General Hospital of Chest Diseases, Athens, Greece; 23rd Oncology Clinic, University of Athens, Athens, Greece; 3Pulmonary Department-Oncology Unit, “G. Papanikolaou” General hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Pulmonary Department- Interventional Unit, “Ruhrland” Clinic, University of Essen, Essen, Germany; 5Department of Clinical Therapeutics, Division of Pulmonology, Medical School of National University of Athens, Greece

Background: The presence of NO as a marker of airway inflammation and indirectly as a general indicator of inflammation and oxidative stress-incrimination as incriminating factor in lung cancer at an early stage and then the treatment of disease after chemotherapy.

Patients and methods: Studied whether exhaled NO levels altered by 3 cycles of chemotherapy the levels at diagnosis and whether directly or indirectly related to the course of disease. Also, correlation levels of NO with other markers of inflammation. We studied 42 patients early diagnosed -26 men and 16 women with lung cancer. We analysed blood tests for control of inflammatory markers, functional pulmonary tests and alveolar exhaled nitric oxide (Tables 1,2).

Table 1
Table 1 Patients characteristics.
Full table
Table 2
Table 2 Histology.
Full table

Results: Recorded decrease in exhaled NO after 3 cycles of chemotherapy in all patients regardless of histological type and stage. 42 patients with a mean 9.8 NO occurs after 3 cycles average 7.7. Also appears strong correlation between NO before and after chemotherapy and CRP (P<0.05, pre chemotherapy) and (P<0.045, after chemotherapy). It is a further breakdown of data by the statistical program SPSS, with subgroups for analysis based histological types (Table 3).

Table 3
Table 3 NO and Laboratory values before initiation and after 3 cycles of chemotherapy.
Full table

Conclusions: NO alveolar as an indicator of airway inflammation, indicates response to chemotherapy in lung cancer. Also the inflammatory process in lung cancer confirmed and indicates response to chemotherapy through an index which is sensitive to inflammatory diseases of the airways and not reused in lung cancer before and after chemotherapy.

Cite this abstract as: Kallianos A, Rapti A, Tsimpoukis S, Charpidou A, Apostolos A, Zarogoulidis P, Porpodis K, Spyratos D, Trakada G, Zarogoulidis K, Syrigos K. Nitric oxide measurements in lung cancer. J Thorac Dis 2012;4(S1):AB60. DOI: 10.3978/j.issn.2072-1439.2012.s060

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