%0 Journal Article %T The large tumor suppressor family: friend or foe? %A Kang, Wei %A Zhou, Yuhang %A To, Ka Fai %J Journal of Thoracic Disease %D 2017 %B 2017 %9 %! The large tumor suppressor family: friend or foe? %K %X In the past few years, Hippo signaling cascade has been a hotspot for scientists who work in the area of cell biology, especially cancer cell biology (1-4). The core components of this pathway in mammalian cells consist of MST1/2 (STE20-like protein kinase 1), MAP4Ks (mitogen-activated protein kinase kinase kinase kinases) and LATS1/2 (the large tumor suppressor 1/2) (5). During the activation of this pathway, LATS1/2 is phosphorylated and activated by MST1/2 or MAP4K family, which directly induces the phosphorylation of YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif). YAP and TAZ lie in the center of Hippo, so their phosphorylation prevents themselves from translocation into the nucleus and therefore stops conveying signals to the downstream (6). %U https://jtd.amegroups.org/article/view/14057 %V 9 %N 7 %P 1748-1751 %@ 2077-6624