TY - JOUR AU - Ryoo, Seung Mok AU - Kang, Gu Hyun AU - Shin, Tae Gun AU - Hwang, Sung Yeon AU - Kim, Kyuseok AU - Jo, You Hwan AU - Park, Yoo Seok AU - Choi, Sung-Hyuk AU - Yoon, Young Hoon AU - Kwon, Woon Yong AU - Suh, Gil Joon AU - Lim, Tae Ho AU - Han, Kap Su AU - Choi, Han Sung AU - Chung, Sung Phil AU - Kim, Won Young AU - Inve, for the Korean Shock Society (KoSS) PY - 2018 TI - Clinical outcome comparison of patients with septic shock defined by the new sepsis-3 criteria and by previous criteria JF - Journal of Thoracic Disease; Vol 10, No 2 (February 14, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Background: We compared the clinical characteristics and outcomes between the new definition of sepsis-3 septic shock and the definition previously used from 1991 until recently. Methods: We conducted an observational study using a prospective, multi-center registry of septic shock from October 2015 to February 2017. Registry data were collected by 10 emergency departments (EDs) in tertiary hospitals that are members of the Korean Shock Society. Data on septic shock patients who met the previous septic shock definition were collected. The patients were divided into a sepsis-3 defined septic shock group, made up of those who met the new criteria for refractory hypotension with hyperlactatemia, and a group of those who met only the 1991 definition for septic shock. The primary outcome was 90-day mortality, and secondary outcomes were 28-day mortality and in-hospital mortality. Results: Of all 1,028 included patients, 574 (55.8%) met the septic shock criteria for sepsis-3, leaving 454 patients who met only the previous definition. Those who met the sepsis-3 criteria demonstrated higher comorbidity than those who met the previous definition (83.1% vs . 75.3%, P vs . 5.0±2.9, 9.3±3.8 vs . 6.6±3.4, and 20.0 (15.0–26.0) vs . 15.0 (10.0–20.3), respectively; P vs . 23.3%; P vs . 17.1% and 25.1% vs . 16.5%, respectively; P Conclusions: The new definition of septic shock successfully selected patients with greater severities and worse outcomes. UR - https://jtd.amegroups.org/article/view/18844