TY - JOUR AU - Briegel, Josef AU - Huge, Volker AU - Möhnle, Patrick PY - 2018 TI - Hydrocortisone in septic shock: all the questions answered? JF - Journal of Thoracic Disease; Vol 10, Supplement 17 (June 20, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Regarding sepsis, a fundamental change in the understanding of the pathophysiology has evolved in the last five decades, from the early concepts of an overwhelming inflammation to disease models increasingly based on the role of a dysregulated host immune response (1). Consequently, the first therapeutic attempts to use corticosteroids in sepsis applied high doses in order to effectively suppress hyper-inflammation. UR - https://jtd.amegroups.org/article/view/20939