TY - JOUR AU - Yamakawa, Hideaki AU - Hagiwara, Eri AU - Iwasawa, Tae AU - Otoshi, Ryota AU - Tabata, Erina AU - Ikeda, Satoshi AU - Okuda, Ryo AU - Baba, Tomohisa AU - Iso, Shinichiro AU - Okudela, Koji AU - Takemura, Tamiko AU - Sato, Shinji AU - Ogura, Takashi PY - 2018 TI - Interstitial lung disease associated with anti-citrullinated peptide/ protein antibody-positive anti-synthetase syndrome JF - Journal of Thoracic Disease; Vol 10, No 10 (October 26, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Little has been reported on the characteristics of interstitial lung disease (ILD) associated with anti-citrullinated peptide/protein antibody (ACPA)-positive anti-synthetase syndrome (ASS). We sought to investigate the clinical, radiologic, and pathologic features of patients with ILD associated with ACPA-positive ASS. Medical records of seven ILD patients with positive results of both ACPA and anti-aminoacyl-tRNA synthetase antibody were retrospectively reviewed. Five patients had clinical symptoms associated with ASS other than ILD. On high-resolution computed tomography (HRCT) analysis, a nonspecific interstitial pneumonia (NSIP) pattern was shown in 3 patients and NSIP with organizing pneumonia (OP) overlap in 2 patients. Coronal slices of these 5 patients showed lower lung disease predominance with traction caudally on major fissures due to lower lobe volume loss. These were features that could commonly be observed in ASS-associated ILD. Pathological findings available for 3 patients showed NSIP. The characteristics of ILD associated with ACPA-positive ASS appear to be similar to those of ILD associated with ASS, but not to rheumatoid arthritis (RA) or ACPA, especially in terms of the radiological findings. UR - https://jtd.amegroups.org/article/view/24310