@article{JTD3235,
author = {Chao Ren and Xiu-Yu Cai and Miao-Zhen Qiu and De-Shen Wang and Feng-Hua Wang and Hui-Yan Luo and Rui-Hua Xu},
title = {Impact of body mass index on survival of esophageal squamous carcinoma patients in southern China},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {3},
year = {2014},
keywords = {},
abstract = {Background: Although high body mass index (BMI) increases risk for developing esophageal adenocarcinoma (EAC), the prognostic influence of BMI is unknown in esophageal squamous carcinoma.
Methods: BMI was calculated using measured height and weight at the first diagnosis and categorized as overweight (25 to 29.9 kg/m2), normal (18.5 to 24.9 kg/m2) or underweight (<18.5 kg/m2). Survival was compared by using the log-rank test on the Kaplan-Meier life table. Multivariate Cox regression analysis was used to evaluate whether BMI was an independent prognostic factor for disease-specific survival (DSS).
Results: Among 1,176 esophageal squamous carcinoma patients, 146 (12.4%) were categorized as overweight, and 277 (23.6%) underweight. More patients in the underweight group had anemia (P=0.001), weight loss (P=0.035) and R1 resection (P<0.001). Less patients in the underweight group received adjuvant chemotherapy (P=0.01). Patients in the overweight group had a higher incidence rate of high blood pressure (P<0.001), diabetes (P<0.001) and coronary artery diseases (P<0.001). Moreover, more patients in the overweight group had a lower TNM stage (P=0.003). In the univariated analysis, high BMI was significantly associated with better DSS (P=0.013).
Conclusions: After adjusting for covariates enrolled for study, high BMI was an independent prognostic factor in weight loss esophageal squamous carcinoma patients.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/3235}
}