TY  - JOUR
AU  - Gitsioudis, Gitsios
AU  - Nunninger, Maximilian
AU  - Missiou, Anna
AU  - Wolf, Peter
AU  - Katus, Hugo A.
AU  - Korosoglou, Grigorios
PY  - 2019
TI  - Multimodality cardiac computed tomography angiography and  magnetic resonance with clinical-grade scanners provide robust  assessment of cardiac morphology and function in rabbits
JF  - Journal of Thoracic Disease; Vol 11, No 11 (November 28, 2019): Journal of Thoracic Disease
Y2  - 2019
KW  - 
N2  -  Background:  Non-invasive computer tomography (CT)- and magnetic resonance (MR)-based cardiac imaging still remains challenging in rodents. To investigate the robustness of non-invasive multimodality cardiac imaging in rabbits using clinical-grade CT and MR scanners.   Methods:  A total of 16 rabbits (2.7–4.0 kg) serially underwent cardiac-gated imaging using a clinical-grade 256-row CT and a 1.5 Tesla MR-scanner at baseline and at 4-month follow-up (16±1 weeks). Image analysis included image quality (5-grade scale), left ventricular (LV) volumes, LV stroke volume, LV diameters, LV wall thickness and ejection fraction (LVEF).   Results:  Cardiac MR (CMR) and CT angiography (CTA) provide images with an overall good image quality (excellent or good quality: CMR 82%  vs.  CTA 78%, P=0.68). Linear regression analysis demonstrated a good correlation of all diameters (diam.) and volumes (vol.) as assessed by CTA and CMR (diam.: r=0.9, 95% CI: 0.8–0.9; vol.: r=0.8, 95% CI: 0.6–0.9; P Conclusions:  Multimodality non-invasive assessment of cardiac function and aortic hemodynamics is feasible and robust in rabbits using clinical-grade and MR and CT scanners. These imaging modalities could improve serial cardiac assessment for disease monitoring in preclinical settings.
UR  - https://jtd.amegroups.org/article/view/33504